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H Kirk Hammond Selected Research

adenylyl cyclase 6

1/2016Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial.
7/2013Adenylyl cyclase 6 deletion increases mortality during sustained β-adrenergic receptor stimulation.
11/2011Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function.
2/2011Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.
4/2010Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice.
10/2007New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.
10/2006Adenylyl cyclase gene transfer in heart failure.
11/2004Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy.
9/2004Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
7/2004Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure.
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H Kirk Hammond Research Topics

Disease

20Heart Failure
01/2020 - 01/2004
9Cardiomyopathies (Cardiomyopathy)
12/2016 - 04/2002
6Myocardial Infarction
01/2019 - 01/2004
5Fibrosis (Cirrhosis)
01/2019 - 04/2010
5Myocardial Ischemia (Ischemic Heart Diseases)
02/2006 - 03/2002
4Insulin Resistance
06/2020 - 01/2016
4Hypertrophy
03/2011 - 07/2006
3Infarction (Infarctions)
10/2013 - 05/2002
2Left Ventricular Dysfunction
01/2019 - 05/2011
2Ischemia
10/2013 - 02/2006
2Atrial Remodeling
11/2010 - 07/2006
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
06/2020
1Dyspnea (Shortness of Breath)
01/2018
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2017
1Cardiotoxicity
01/2017
1Reperfusion Injury
10/2013
1Coronary Occlusion
03/2012
1Stroke (Strokes)
03/2012
1Hypoxia (Hypoxemia)
11/2011
1Cardiovascular Diseases (Cardiovascular Disease)
10/2011
1Atherosclerosis
10/2011
1Cardiomegaly (Heart Hypertrophy)
11/2010
1Congenital Heart Defects (Congenital Heart Defect)
06/2010
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
04/2010
1Neoplasms (Cancer)
10/2007
1Atrioventricular Block
08/2006
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
11/2004
1Hypothermia
07/2004
1Ventricular Dysfunction
06/2004
1Vascular Diseases (Vascular Disease)
06/2004
1Coronary Artery Disease (Coronary Atherosclerosis)
06/2004
1Ventricular Remodeling
01/2004

Drug/Important Bio-Agent (IBA)

11adenylyl cyclase 6IBA
01/2016 - 04/2002
8Proteins (Proteins, Gene)FDA Link
01/2019 - 06/2004
8Adenylyl Cyclases (Adenylyl Cyclase)IBA
01/2018 - 04/2002
6UrocortinsIBA
06/2020 - 01/2016
4Glucose (Dextrose)FDA LinkGeneric
06/2020 - 01/2016
4Peptides (Polypeptides)IBA
01/2019 - 09/2013
3Blood Glucose (Blood Sugar)IBA
06/2020 - 01/2016
3Adrenergic Receptors (Adrenergic Receptor)IBA
01/2017 - 05/2011
3Protein Isoforms (Isoforms)IBA
11/2010 - 01/2004
3Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
02/2006 - 03/2002
3Messenger RNA (mRNA)IBA
09/2005 - 05/2002
2Insulin (Novolin)FDA Link
06/2020 - 01/2016
2IntegrinsIBA
01/2017 - 10/2013
2Caspase 3 (Caspase-3)IBA
01/2017 - 03/2012
2AntibodiesIBA
10/2011 - 02/2006
2CollagenIBA
05/2011 - 04/2010
2Atrial Natriuretic Factor (ANF)IBA
05/2011 - 05/2002
2phospholambanIBA
03/2011 - 08/2006
2CalciumIBA
08/2006 - 11/2004
1Inositol (Myoinositol)IBA
03/2019
1Phospholipids (Phosphatides)FDA LinkGeneric
03/2019
1salicylhydroxamic acid (SHAM)IBA
01/2019
1Corticotropin-Releasing HormoneIBA
01/2019
1pro-brain natriuretic peptide (1-76)IBA
01/2018
1AnthracyclinesIBA
01/2017
1Daunorubicin (Cerubidine)FDA LinkGeneric
01/2017
1Pharmaceutical PreparationsIBA
01/2017
1CaveolinsIBA
01/2017
1CatecholaminesIBA
12/2016
1Insulin-Like Growth Factor I (IGF-1)IBA
03/2012
1Doxycycline (Periostat)FDA LinkGeneric
03/2012
1DobutamineFDA LinkGeneric
03/2012
1Drinking WaterIBA
03/2012
1ColforsinIBA
11/2011
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
11/2011
1Phosphates (Orthophosphate)IBA
10/2011
1Single-Chain AntibodiesIBA
10/2011
1Scavenger Receptors (Scavenger Receptor)IBA
10/2011
1LDL Receptors (LDL Receptor)IBA
10/2011
1enhanced green fluorescent proteinIBA
10/2011
1oxidized low density lipoproteinIBA
10/2011
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
05/2011
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
03/2011
1Protein Kinase CIBA
11/2010
1adenylyl cyclase type VIBA
11/2010
1Gq-G11 GTP-Binding Protein alpha Subunits (Gq Protein)IBA
11/2010
1Prostaglandins EIBA
06/2010
1PeriostinIBA
04/2010
1RNA (Ribonucleic Acid)IBA
04/2010
1Adenosine Monophosphate (AMP)IBA
08/2006
1Adenosine Triphosphatases (ATPase)IBA
08/2006
1ameroidIBA
02/2006
1ElementsIBA
09/2005
1Fibroblast Growth Factor 5IBA
09/2005
1Fibroblast Growth Factor 4IBA
09/2005
1Protein Sorting Signals (Signal Peptide)IBA
09/2005
1Angiogenic ProteinsIBA
09/2005
1Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
07/2004
1Serotonin (5 Hydroxytryptamine)IBA
07/2004
1Acetylcholine (Acetylcholine Chloride)FDA Link
07/2004
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2004
1Protein Kinase C-epsilonIBA
01/2004
1Angiotensin Receptors (Angiotensin II Receptor)IBA
01/2004

Therapy/Procedure

7Therapeutics
06/2020 - 06/2004
2Ligation
06/2015 - 08/2006
1Intravenous Injections
06/2020
1Percutaneous Coronary Intervention
06/2004
1Coronary Artery Bypass (Coronary Artery Bypass Surgery)
06/2004